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KMID : 0356419930110010023
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Journal of Korean Andrology
1993 Volume.11 No. 1 p.23 ~ p.28
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Effect of Terazosin in Symptomatic Benign Prostatic Hyperplasia
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민영기
성도환/최학룡/홍성준/이무상
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Abstract
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We investigated the effectiveness of terazosin in symptomatic benign prostatic hyperplasia (BPH) in 31 evaluable patients. After 2 weeks of treatment, the initial dosage of 2 mg/day was elevated to 4gm/day in 17 randomly chosen patients. At 12
weeks'
follow-up, 55% of the patients had>30% improvement in their symptom scores, and 32% had a>30% increase in their maximal flow rate. The maximal effect was achieved at 2 weeks, with no further improvement seen thereafter inpatients who had not
already
responded. There was no significant difference between the 2-mg and 4-mg doses. We concluded that terazosin is effective in some patients with infravesical obstruction secondary to BPH. Further studies are needed to evaluate the effect of
increasing the
dose in patients who do not respond to initial low-dose therapy.
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KEYWORD
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